ERYTHROPOIESIS Erythropoiesis constitute 10-30% of hemopoietic cells in the bone marrow. The mature erythrocyte is derived from the stem cell, which differentiate to erythroid colony forming cells (BFU-E, CFU-E), and next to the proerythroblast, the first morphologically recognizable cell of the series. The proerythroblast matures to the basophilic normoblast, then the polichromatic normoblast, where synthesis of hemoglobin is started. At the end, the polychromatophilic normoblast matures to the orthochromatic normoblast. The orthochromatic normoblast loses its nucleus and developes into reticulocyte, which after 2-4 days develops into mature erythrocyte. The mature erythrocyte stays for ca. 4 months in the blood. | |
| Proerythroblasts | Basophilic (early) normoblast |
| Polychromatic (intermediate) normoblas | Pycnotic (late) normoblast |
| Reticulocytes | Normocytes |
| Microcytes | Macrocytes |
| Megalocytes | Anisocytosis |
| Hypochromia | Polychromasia |
| Eliptocytes | Lacrymocytes |
| Target cells | Acanthocytes |
| Echinocytes | Crenated red blood cells |
| Schistocytes | Stomatocytes |
| Spherocytes | Leptocytes |
| Anulocytes | Sickle cells |
| Poikilocytosis | Howell-Jolly bodies |
| Cabot rings | Basophilic stippling |
| Pappenheimer bodies | Normoblasts in blood |
Thursday, October 23, 2008
ATLUS HEAMATOLOGY
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